検索タンパク質、抗体、アッセイキット
タンパク質カタログ
輸入に関する法規制チェックは、御見積のご依頼をいただいた際に行います。
法規制によっては、定価として記載の価格に追加の費用が発生する場合や供給出来ない場合がございますので、あらかじめご了承ください。
- サプライヤー
- TargteMol
- カタログNo.
- TMPY-01897
- 製品名称
- PRSS3 Protein, Human, Recombinant (His)
- タンパク質名
- PRSS3
- Species
- Human
- HOST
- HEK293 Cells
- 50μg: -
- お問い合わせ
Overview
| Synonyms | TRY3, RP11-176F3.3, T9, MTG, PRSS4, TRY4, protease, serine 3 |
|---|---|
| Characteristics | Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2. The specific activity is >4,000 pmoles/min/μg. (Activation description: The proenzyme needs to be activated by enteropeptidase for an activated form) |
| Endotoxin Level | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Purity | 98.60% |
| Description | Trypsin-3, also known as Trypsin III, brain trypsinogen, Serine protease 3 and PRSS3, is a secreted protein that belongs to the peptidase S1 family. Trypsin-3 / PRSS3 is expressed is in pancreas and brain. It contains one peptidase S1 domain. Trypsin-3 / PRSS3 can degrade intrapancreatic trypsin inhibitors that protect against CP. Genetic variants that cause higher mesotrypsin activity might increase the risk for chronic pancreatitis (CP). A sustained imbalance of pancreatic proteases and their inhibitors seems to be important for the development of CP. The trypsin inhibitor-degrading activity qualified PRSS3 as a candidate for a novel CP susceptibility gene. Trypsin-3 / PRSS3 has been implicated as a putative tumor suppressor gene due to its loss of expression, which is correlated with promoter hypermethylation, in esophageal squamous cell carcinoma and gastric adenocarcinoma. |
| Reference | Rowen, L. et al., 2005, Mol Biol Evol. 22?(8):1712-20.,Venter JC. et al., 2001, Science 291:1304-51.,Marsit,CJ. et al., 2005,?Mol Carcinog?44?(2):146-50.,Rosendahl, J. et al., 2010, Pancreatology. 10?(2-3):243-9 |
| URL | https://www.targetmol.com/recombinant-protein/prss3_protein_human_recombinant_his_tag_ |
お問い合わせリスト