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サプライヤー
TargteMol
カタログNo.
TMPY-01850
製品名称
CEACAM3 Protein, Human, Recombinant (His)
タンパク質名
CEACAM3
Species
Human
HOST
HEK293 Cells
50μg: -
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Overview

Synonyms W282, W264, CEA, CD66D, CGM1, MGC119875, carcinoembryonic antigen related cell adhesion molecule 3
Characteristics Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Endotoxin Level < 1.0 EU/μg of the protein as determined by the LAL method.
Purity 98%
Description CeACAM3 (CD66d), a member of carcinoembryonic antigen family, is a granulocyte-specific receptor involved in the opsonin-independent recognition of several bacterial pathogens. There are four members in this family: CD66a, CD66b, CD66c, and CD66d. Members of CEACAM family are widely expressed especially on human neutrophils, and, depending on the tissue, capable of regulating diverse functions including tumor promotion, tumor suppression, angiogenesis, and neutrophil activation. Abnormal overexpression and downregulation of some CEACAMs have been described in tumor cells. Monoclonal antibodies grouped in the CD66 cluster recognize CEACAM members. Ectopic CD66 expression is commonly detected in B-cell lineage acute lymphoblastic leukemia (ALL). CEACAM3 mediates phagocytosis depends on the integrity of an ITAM-like sequence within the cytoplasmic domain of CEACAM3. CEACAM3 is characterized by rapid stimulation of the GTPase Rac.
Reference Ichikawa K,et al.(2003) TRAIL-R2 (DR5) mediates apoptosis of synovial fibroblasts in rheumatoid arthritis. J Immunol. 171(2): 1061-9.,Schneider P,et al.(1997) TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB. Immunity. 7(6): 831-6.
URL https://www.targetmol.com/recombinant-protein/ceacam3_protein_human_recombinant_his_tag_

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