HMGB1 Protein, Human, Recombinant (aa 1-215, His) [TMPY-01848]

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Synonyms	SBP-1, high mobility group box 1, HMG-1, HMG3, HMG1
Characteristics	Measured by its binding ability in a functional ELISA. Immobilized human HMGB at 2 μg/ml (100 μl/well) can bind human AGER. The EC50 of human AGER is 0.27 μg/ml.
Endotoxin Level	< 1.0 EU/μg of the protein as determined by the LAL method.
Purity	SDS-PAGE: 98.6%; SEC-HPLC: 97.3%
Description	HMGB1 Protein, Human, Recombinant (aa 1-215, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.3 kDa and the accession number is A0A024RDR0.
Reference	Ulloa L,et al.(2006) High-mobility group box 1 (HMGB1) protein: friend and foe. Cytokine Growth Factor Rev. 17 (3): 189-201.,Andersson U,et al.(2010) The role of HMGB1 in the pathogenesis of rheumatic disease. Biochim Biophys Acta. 1799 (1-2): 141-8.,Sims GP,et al.(2010) HMGB1 and RAGE in inflammation and cancer. Annu Rev Immunol. 28: 367-88.,Volz HC,et al.(2010) The role of HMGB1/RAGE in inflammatory cardiomyopathy. Semin Thromb Hemost. 36(2): 185-94.,Pisetsky DS,et al.(2008) High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease. Arthritis Res Ther. 10 (3): 209.
URL	https://www.targetmol.com/recombinant-protein/hmgb1_protein_human_recombinant_his_tag_hplc_verified

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