4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (His) [TMPY-01743]

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Synonyms	4-1BB, CD137, ILA, CDw137, tumor necrosis factor receptor superfamily, member 9
Characteristics	Measured by its binding ability in a functional ELISA. Immobilized Human 4-1BB-His at 2 μg/ml (100 μl/well) can bind human 4-1BBL-hFc , the EC50 of human 4-1BBL-hFc is 8-40 ng/mL.
Endotoxin Level	< 1.0 EU/μg of the protein as determined by the LAL method.
Purity	SDS-PAGE: 92.3%; SEC-HPLC: 94.4%
Description	4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18.8 kDa and the accession number is Q07011.
Reference	Melero I,et al.(2008) Multi-layered action mechanisms of CD137 (4-1BB)-targeted immunotherapies. Trends Pharmacol Sci. 29(8): 383-90.,Wang Q,et al.(2008) Analysis of CD137 and CD137L expression in human primary tumor tissues. Croat Med J. 49(2): 192-200.,Thum E,et al.(2009) CD137, implications in immunity and potential for therapy. Front Biosci. 14: 4173-88.,Nam KO,et al.(2005)?The therapeutic potential of 4-1BB (CD137) in cancer.?Curr Cancer Drug Targets. 5(5): 357-63.,Sica G,et al.(1999) Biochemical and immunological characteristics of 4-1BB (CD137) receptor and ligand and potential applications in cancer therapy. Arch Immunol Ther Exp (Warsz). 47(5): 275-9.
URL	https://www.targetmol.com/recombinant-protein/4_1bb_cd137_protein_human_recombinant_ecd_his_tag_hplc_verified

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