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- サプライヤー
- TargteMol
- カタログNo.
- TMPY-01648
- 製品名称
- TREML2 Protein, Human, Recombinant (His)
- タンパク質名
- TREML2
- Species
- Human
- HOST
- HEK293 Cells
- 100μg: -
- お問い合わせ
Overview
| Synonyms | UNQ6268/PRO20473, MGC149715, TLT2, dJ238O23.1, triggering receptor expressed on myeloid cells like 2, TLT-2, MGC149716, FLJ13693, C6orf76 |
|---|---|
| Characteristics | Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Endotoxin Level | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Purity | 94.70% |
| Description | Trem-like transcript 2 protein, also known as Triggering receptor expressed on myeloid cells-like protein 2, TREML2 and TLT2, is a single-pass type I membrane protein that contains one Ig-like V-type (immunoglobulin-like) domain. TREML2 is detected in cultured B cells, T cell leukemia and monocyte leukemia. TREML2 is expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation. TREML2 is a cell surface receptor that may play a role in the innate and adaptive immune response. TREML2 acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation. Murine B7-H3 is specifically bound to Triggering receptor expressed on myeloid cells (TREM)-like transcript 2 (TLT-2, TREML2). TREML2 was expressed on CD8(+) T cells constitutively and on activated CD4(+) T cells. Stimulation with B7-H3 transfectants preferentially up-regulated the proliferation and IFN-gamma production of CD8(+) T cells. Transduction of TREML2 into T cells resulted in enhanced IL-2 and IFN-gamma production via interactions with B7-H3. There may be a direct interaction between B7-H3 and TREML2 that preferentially enhances CD8(+) T cell activation. |
| Reference | The MGC Project Team. et al., 2004, Genome Res. 14:2121-7.,Clark HF. et al., 2003, Genome Res. 13: 2265-70.,Hashiguchi M., et al., 2008, Proc. Natl.Acad. Sci. USA.105:10495-500.,Leitner,J. et al., 2009,?Eur J Immunol. 39?(7):1754-64.,Mungall A.J. et al., 2003, Nature. 425: 805-11. |
| URL | https://www.targetmol.com/recombinant-protein/treml2_protein_human_recombinant_his_tag_ |
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