IL-17RA Protein, Human, Recombinant (His) [TMPY-01371]

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Synonyms	CANDF5, CD217, CDw217, IL-17RA, hIL-17R, IL17R, interleukin 17 receptor A
Characteristics	1. Measured by its binding ability in a functional ELISA. Immobilized recombinant human IL17A at 2 μg/ml (100 μl/well) can bind biotinylated human IL17RA with a linear range of 1.28-32 ng/ml. 2. Measured by its ability to inhibit IL-17-induced IL-6 secretion by NIH?3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 0.2?1.2?g/mL in the presence of 5?ng/mL recombinant human IL?17.
Endotoxin Level	< 1.0 EU/μg of the protein as determined by the LAL method.
Purity	99.50%
Description	IL-17RA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35 kDa and the accession number is Q96F46-1.
Reference	Johansen C, et al.. (2009) Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin. Br J Dermatol. 160 (2): 319-24.,Yao Z, et al.. (1997) Molecular characterization of the human interleukin (IL)-17 receptor. Cytokine 9 (11): 794-800.,Gaffen SL. (2009) Structure and signalling in the IL-17 receptor family. Nat Rev Immunol. 9 (8): 556-67.
URL	https://www.targetmol.com/recombinant-protein/il17ra_protein_human_recombinant_ecd_his_tag_

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