DLL4 Protein, Human, Recombinant (His) [TMPY-01321]

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Synonyms	hδ2, Delta-like 4, delta-like 4 (Drosophila), hdelta2, δ-like 4 (Drosophila), δ-like 4
Characteristics	1. Measured by its ability to bind human Notch1 in a functional ELISA. 2. Measured by the ability of the immobilized protein to enhance BMP2-induced alkaline phosphatase activity in C3H10T1/2 mouse embryonic fibroblast cells. The ED50 for this effect is typically 2-10 ?g/mL in the presence of 500 ng/mL recombinant human BMP2.
Endotoxin Level	< 1.0 EU/μg of the protein as determined by the LAL method.
Purity	98.60%
Description	DLL4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55.7 kDa and the accession number is Q9NR61.
Reference	Li JL,et al.(2010) Targeting DLL4 in tumors shows preclinical activity but potentially significant toxicity. Future Oncol. 6(7): 1099-103.,Sainson RC,et al.(2007) Anti-Dll4 therapy: can we block tumour growth by increasing angiogenesis? Trends Mol Med. 13(9): 389-95.,Yan M,et al.(2007) Delta-like 4/Notch signaling and its therapeutic implications. Clin Cancer Res. 13(24): 7243-6.,Martinez JC,et al.(2009) Nuclear and membrane expression of the angiogenesis regulator delta-like ligand 4 (DLL4) in normal and malignant human tissues. Histopathology. 54(5): 598-606.
URL	https://www.targetmol.com/recombinant-protein/dll4_protein_human_recombinant_his_tag_hplc_verified

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