OSMR Protein, Human, Recombinant (His) [TMPY-01305]

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Synonyms	OSMRB, PLCA1, oncostatin M receptor, IL-31RB
Characteristics	1.Loaded Anti-Human OSMR antibody, human IgG1 on ProA?Biosensor, can bind Recombinant Human OSMR Protein, His Tag with an affinity constant of 0.40 nM as determined in a BLI assay (Routinely tested). 2. Immobilized Anti-OSMRβ Antibody at 2 μg/mL (100 μL/well) can bind Recombinant Human OSMR / IL31RB Protein (His Tag), the EC50 is 4-12 ng/mL.
Endotoxin Level	< 1.0 EU/μg of the protein as determined by the LAL method.
Purity	SDS-PAGE: 97.6%; SEC-HPLC: 90.7%
Description	OSMR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 82.6 kDa and the accession number is Q99650-1.
Reference	Arita K, et al.. (2008) Oncostatin M Receptor-β Mutations Underlie Familial Primary Localized Cutaneous Amyloidosis. Am J Hum. Genet. 82 (1): 73-80.,Lin MW, et al.. (2010) Novel IL31RA gene mutation and ancestral OSMR mutant allele in familial primary cutaneous amyloidosis. Eur J Hum Genet. 18(1): 26-32.,Malaval L, et al.. (2005) GP130/OSMR is the only LIF/IL-6 family receptor complex to promote osteoblast differentiation of calvaria progenitors. J Cell Physiol. 204(2): 585-93.
URL	https://www.targetmol.com/recombinant-protein/osmr_protein_human_recombinant_his_tag_hplc_verified

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