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- サプライヤー
- TargteMol
- カタログNo.
- TMPY-01280
- 製品名称
- FOLR2 Protein, Human, Recombinant (His)
- タンパク質名
- FOLR2
- Species
- Human
- HOST
- HEK293 Cells
- 100μg: -
- お問い合わせ
Overview
| Synonyms | FR-P3, BETA-HFR, FBP, β-HFR, folate receptor 2 (fetal), FR-BETA, FR-β, FBP/PL-1 |
|---|---|
| Characteristics | Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Endotoxin Level | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Purity | 98.60% |
| Description | Folate receptor beta, also known as Folate receptor 2, FBP, and FOLR2, is a member of the folate receptor family. FOLR2 is expressed in placenta and hematopoietic cells. The expression of FOLR2 is increased in malignant tissues. Members of the Folate receptor family members (FOLRs) have a high affinity for folic acid and for several reduced folic acid derivatives. They mediate the delivery of 5-methyltetrahydrofolate to the interior of, out of within, or between cells in a process known as potocytosis. FOLR2 has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus. FOLR2 is a marker for macrophages generated in the presence of M-CSF, but not GM-CSF. Its expression correlates with increased folate uptake ability. Folate conjugates of therapeutic drugs are a potential immunotherapy tool to target tumor-associated macrophages. |
| Reference | van Heyningen V, et al., 1995, Cytogenet Cell Genet. 69?(3-4): 127-58.,Scapoli, L. et al., 2005, Am J Med Genet A. 132A?(3): 302-4.,Puig-Kr?ger, A. et al., 2009, Cancer Res??69?(24): 9395-403.,Sabharanjak, S. et al., 2004,?Adv Drug Deliv Rev. 56?(8): 1099-109. |
| URL | https://www.targetmol.com/recombinant-protein/folr2_protein_human_recombinant_his_tag_ |
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