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- サプライヤー
- TargteMol
- カタログNo.
- TMPY-01137
- 製品名称
- HER2/ERBB2 Protein, Human, Recombinant (aa 1-652, His)
- タンパク質名
- HER2/ERBB2
- Species
- Human
- HOST
- HEK293 Cells
- 100μg: -
- お問い合わせ
Overview
| Synonyms | erb-b2 receptor tyrosine kinase 2, NEU, ENVW, HERVW, HER-2, CD340, NGL, HER2, HERV7Q, HERV-7q, HER-2/neu, MLN 19, ENV, TKR1, EGFR2, HERV-W-ENV, MLN19, HERVWENV, ERVWE1 |
|---|---|
| Characteristics | 1. Immobilized Her2/ERBB2 Protein, Human, Recombinant (ECD, His Tag) at 2 μg/ml (100 μl/well) can bind Anti-Erbb2 Antibody (Trastuzumab), the EC50 is 10-60 ng/mL. 2. Measured by its ability to block anti-ErbB2 mediated inhibition of BT474 human breast ductal carcinoma cell proliferation. The ED50 for this effect is 0.2-1 μg/mL in the presence of 0.6 ?g/mL Anti-ErbB2/Her2 Monoclonal Antibody. 3. Using the Octet RED System, the affinity constant (Kd) of Her2 / ERBB2 Protein, Human, Recombinant (His Tag) bound to Pertuzumab was 0.1 nM. 4.Captured anti-Her2 IgG1 antibody on proA Chip can bind Her2 with?an?affinity constant of 3.270 nM?as determined?in a SPR assay (Routinely tested). 5.Captured Trastuzumab on?proA Chip can bind Her2 with an affinity constant of 3.727 nM as determined?in a SPR?assay(Routinely tested). |
| Endotoxin Level | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Purity | SDS-PAGE: 87.9%; SEC-HPLC: 93% |
| Description | HER2/ERBB2 Protein, Human, Recombinant (aa 1-652, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71 kDa and the accession number is P04626-1. |
| Reference | Krawczyk N,et al.(2009) HER2 status on persistent disseminated tumor cells after adjuvant therapy may differ from initial HER2 status on primary tumor. Anticancer Res. 29(10): 4019-24. |
| URL | https://www.targetmol.com/recombinant-protein/her2_erbb2_protein_human_recombinant_ecd_his_tag_hplc_verified |
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