FGFR1 Protein, Human, Recombinant (His) [TMPY-01011]

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Synonyms	KAL2, FLT2, FGFBR, HRTFDS, OGD, FLG, HBGFR, bFGF-R-1, CD331, fibroblast growth factor receptor 1, CEK, BFGFR, FLT-2, HH2, N-SAM, FGFR-1
Characteristics	1.Measured by its ability to inhibit FGF-acidic dependent proliferation of Balb/c 3T3 mouse fibroblasts.?The ED50 for this effect is typically 40-300 ng/mL. 2.Loaded Recombinant Human FGFR1 Protein, His Tag on His1K Biosensor, can bind Recombinant Human FGF1 Protein, no Tag with an affinity constant of 2.87 nM as determined in BLI assay (QC tested).
Endotoxin Level	< 1.0 EU/μg of the protein as determined by the LAL method.
Purity	98.40%
Description	FGFR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31 kDa and the accession number is H9FRD4.
Reference	Dod? C,et al.(2007) Novel FGFR1 sequence variants in Kallmann syndrome, and genetic evidence that the FGFR1c isoform is required in olfactory bulb and palate morphogenesis. Hum Mutat. 28(1): 97-8.,Kim HG,et al.(2005) Hypogonadotropic hypogonadism and cleft lip and palate caused by a balanced translocation producing haploinsufficiency for FGFR1. J Med Genet. 42(8):666-72.,Schlessinger J,et al.(2000) Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization. Mol Cell. 6(3):743-50.
URL	https://www.targetmol.com/recombinant-protein/fgfr1_protein_human_recombinant_his_tag_

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