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- サプライヤー
- TargteMol
- カタログNo.
- TMPY-00897
- 製品名称
- PD-1 Protein, Human, Recombinant (His)
- タンパク質名
- PD-1
- Species
- Human
- HOST
- HEK293 Cells
- 100μg: -
- お問い合わせ
Overview
| Synonyms | PD1, hPD-l, hPD-1, CD279, programmed cell death 1, hSLE1, SLEB2, PD-1 |
|---|---|
| Characteristics | 1. Immobilized human PD-1 at 2 μg/ml (100 μl/well) can bind PD-L1 Protein, Human, Recombinant (ECD, hFc Tag) , the EC50 of human B7-H1 is 150-600 ng/mL.<br> 2. Immobilized human PD-1 at 2 μg/mL (100 μL/well) can bind Anti-PD1(MDX)-IgG4 Antibody (Nivolumab), the EC50 is 8-60 ng/mL.<br> 3. Loaded Anti-human PD1 antibody, IgG4 on ProA Biosensor, can bind Recombinant Human PD1 Protein, His Tag with an affinity constant of 2.44 nM as determined in a BLI assay (Sartorius Octet RED384) (Routinely tested).<br> 4.Captured Anti-PD1 Mab (Human IgG4) on?proA Chip can?bind PD1 with an affinity constant of 10.03nM as determined in a SPR assay(Routinely tested) . |
| Endotoxin Level | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Purity | SDS-PAGE: 97.8%; SEC-HPLC: 99.8% |
| Description | PD-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.4 kDa and the accession number is A0A0M3M0G7. |
| Reference | Okazaki T, et al. (2007) PD-1 and PD-1 ligands: from discovery to clinical application. Int Immunol. 19(7): 813-24.,James ES, et al. (2005) PDCD1: a tissue-specific susceptibility locus for inherited inflammatory disorders. Genes Immun. 6(5): 430-7.,del Rio ML, et al. (2008) PD-1/PD-L1, PD-1/PD-L2, and other co-inhibitory signaling pathways in transplantation. Transpl Int. 21(11): 1015-28.,Riley JL.(2009) PD-1 signaling in primary T cells. Immunol Rev. 229(1): 114-25. |
| URL | https://www.targetmol.com/recombinant-protein/pd_1_protein_human_recombinant_ecd_his_tag_hplc_verified |
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