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- サプライヤー
- TargteMol
- カタログNo.
- TMPY-00864
- 製品名称
- IL-6R Protein, Human, Recombinant (His)
- タンパク質名
- IL-6R
- Species
- Human
- HOST
- HEK293 Cells
- 100μg: -
- お問い合わせ
Overview
| Synonyms | interleukin 6 receptor, IL6RA, IL6RQ, IL-6R, gp80, IL-6R-1, IL-6RA, IL6Q, CD126 |
|---|---|
| Characteristics | 1. Immobilized Recombinant Human IL6 / Interleukin-6 Protein at 2 μg/mL (100 μL/well) can bind Recombinant Human IL6R / CD126 Protein (His Tag) , the EC50 is 8-24 ng/mL. 2. Measured by its ability to enhance the IL6 activity on M1 mouse myeloid leukemia cells. The ED50 for this effect is typically 20-80 ng/mL. 3. Using the Octet RED System, the affinity constant (Kd) of IL-6R Protein, Human, Recombinant (His Tag) bound Anti-IL6R Antibody was 0.1 nM. 4.Loaded Recombinant Human IL-6R Protein, His Tag on His1K Biosensor, can bind Recombinant Human IL-6 Protein, no Tag with an affinity constant of 0.165 ?M as determined in BLI assay(Routinely tested). |
| Endotoxin Level | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Purity | SDS-PAGE: 93.8%; SEC-HPLC: 95.7% |
| Description | IL-6R Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is A0N0L5. |
| Reference | Barill S, et al. (2000) The role of interleukin-6 and interleukin-6/interleukin-6 receptor-alpha complex in the pathogenesis of multiple myeloma. Eur Cytokine Netw. 11(4): 546-51.,Kang KW, et al. (2007) Novel role of IL-6/SIL-6R signaling in the expression of inducible nitric oxide synthase (iNOS) in murine B16, metastatic melanoma clone F10.9, cells. Free Radic Biol Med. 42(2): 215-27. |
| URL | https://www.targetmol.com/recombinant-protein/il_6r_protein_human_recombinant_ecd_his_tag_hplc_verified |
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