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- サプライヤー
- TargteMol
- カタログNo.
- TMPY-00817
- 製品名称
- Granzyme B/GZMB Protein, Human, Recombinant (His)
- タンパク質名
- Granzyme B/GZMB
- Species
- Human
- HOST
- HEK293 Cells
- 50μg: -
- お問い合わせ
Overview
| Synonyms | CGL1, CTLA1, CSP-B, CTSGL1, HLP, SECT, CSPB, granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1), CCPI, CGL-1 |
|---|---|
| Characteristics | Measured by its ability to cleave a peptide substrate, tButyloxycaronylAlaAlaAspThioBenzylester (BocAADSBzl),in the presence of 5,5’Dithiobis (2nitrobenzoic acid) (DTNB). The specific activity is >1500 pmol/min/μg. (The enzyme needs to be activated by Recombinant Mouse Active Cathepsin C) |
| Endotoxin Level | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Purity | SDS-PAGE: 96%; SEC-HPLC: 98.0% |
| Description | Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the target cells depending on another membrane-binding granule protein, perforin, results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Over 3 substrates of GZMB have been identified including the key substrate caspase-3, ICAD, and Bid. GZMB is suggested to protect the host by lysing cells bearing on their surface 'nonself' antigens such as bacterial and viral infected-cells and tumor cells and accordingly plays an essential role in immunosurveillance. |
| Reference | Trapani J.A.,et al.,(1988), Molecular cloning of an inducible serine esterase gene from human cytotoxic lymphocytes.Proc. Natl. Acad. Sci. U.S.A. 85:6924-6928.,Schmid J.,et al.,(1987), Induction of mRNA for a serine protease and a beta-thromboglobulin-like protein in mitogen-stimulated human leukocytes. J. Immunol. 139:250-256.,Caputo A.,et al., (1988), Structure and differential mechanisms of regulation of expression of a serine esterase gene in activated human T lymphocytes.J. Biol. Chem. 263:6363-6369. |
| URL | https://www.targetmol.com/recombinant-protein/granzyme_b_protein_human_recombinant_his_tag_hplc_verified |
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