DLL4 Protein, Human, Recombinant (hFc) [TMPY-00776]

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Synonyms	δ-like 4 (Drosophila), Delta-like 4, hdelta2, delta-like 4 (Drosophila), hδ2, δ-like 4
Characteristics	1. Measured by its binding ability in a functional ELISA. Immobilized Mouse NOTCH1-His at 2 μg/ml (100 μl/well) can bind human DLL4-hFc , the EC50 of human DLL4-hFc is 15-90 ng/mL. 2. Measured by the ability of the immobilized protein to enhance BMP2-induced alkaline phosphatase activity in C3H10T1/2 mouse embryonic fibroblast cells. The ED50 for this effect is typically 1-8 ?g/mL in the presence of 500 ng/mL recombinant human BMP2.
Endotoxin Level	< 1.0 EU/μg of the protein as determined by the LAL method.
Purity	95.80%
Description	DLL4 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 81 kDa and the accession number is Q9NR61.
Reference	Martinez JC,et al.(2009) Nuclear and membrane expression of the angiogenesis regulator delta-like ligand 4 (DLL4) in normal and malignant human tissues. Histopathology. 54(5): 598-606.,Li JL,et al.(2010) Targeting DLL4 in tumors shows preclinical activity but potentially significant toxicity. Future Oncol. 6(7): 1099-103.,Yan M,et al.(2007) Delta-like 4/Notch signaling and its therapeutic implications. Clin Cancer Res. 13(24): 7243-6.,Sainson RC,et al.(2007) Anti-Dll4 therapy: can we block tumour growth by increasing angiogenesis? Trends Mol Med. 13(9): 389-95.
URL	https://www.targetmol.com/recombinant-protein/dll4_protein_human_recombinant_ecd_hfc_tag_hplc_verified

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