COMP Protein, Human, Recombinant (His) [TMPY-00725]

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Synonyms	THBS5, MED, EPD1, PSACH, cartilage oligomeric matrix protein, EDM1
Characteristics	Measured by its ability to induce adhesion of ATDC5 mouse chondrogenic cells. When cells are added to COMP-coated plates (0.625 μg/mL and 100 μL/well), approximately >30% cells will adhere specifically after 60 minutes at 37℃.
Endotoxin Level	< 1.0 EU/μg of the protein as determined by the LAL method.
Purity	89.60%
Description	Cartilage Oligomeric Matrix Protein (COMP), also referred to as Thrombospondin-5, is a non-collagenous extracellular matrix (ECM) protein and belongs to the subgroup B of the thrombospondin protein family. This protein is expressed primarily in cartilage, ligament, and tendon, and binds to other ECM proteins such as collagen I, II and IX with high affinities depending on the divalent cations Zn2+ or Ni2+. COMP is a secreted glycoprotein that is important for growth plate organization and function. It is suggested to play a role in cell growth and development, and recent studies have revealed the possible mechanism that it protects cells against death by elevating members of the IAP (inhibitor of apoptosis protein) family of survival proteins. Mutations in COMP cause two skeletal dysplasias, pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (EDM1), and up-regulated expression of COMP are observed in rheumatoid arthritis and certain carcinomas.
Reference	4929
URL	https://www.targetmol.com/recombinant-protein/comp_protein_human_recombinant_his_tag_

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