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- サプライヤー
- TargteMol
- カタログNo.
- TMPY-00654
- 製品名称
- ACVR2B Protein, Human, Recombinant (hFc)
- タンパク質名
- ACVR2B
- Species
- Human
- HOST
- HEK293 Cells
- 100μg: -
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Overview
| Synonyms | activin A receptor, type IIB, HTX4, ActR-IIB, ACTRIIB, Activin RIIB |
|---|---|
| Characteristics | 1. Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation. The ED50 for this effect is typically 0.02-0.1 ?g/mL in the presence of 10 ng/mL recombinant Activin A. 2. Measured by its binding ability in a functional ELISA. Immobilized Inhibin Human, Mouse, Rat, Cynomolgus, Rhesus Inhibin beta A/Activin A at 2 μg/ml (100 μl/well) can bind Human ACVR2B hFc, the EC50 of Human ACVR2B hFc is 12-60 ng/mL. |
| Endotoxin Level | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Purity | SDS-PAGE: 95.4%; SEC-HPLC: 99.2% |
| Description | ACVR2B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.0 kDa and the accession number is Q13705-1. |
| Reference | Kosaki R,et al.(1999) Left-right axis malformations associated with mutations in ACVR2B, the gene for human activin receptor type IIB. Am J Med Genet. 82(1):70-6.,Walsh S,et al.(2007) Activin-type II receptor B (ACVR2B) and follistatin haplotype associations with muscle mass and strength in humans. J Appl Physiol. 102(6):2142-8.,Dupont S,et al.(2001) No evidence for linkage or for diabetes-associated mutations in the activin type 2B receptor gene (ACVR2B) in French patients with mature-onset diabetes of the young or type 2 diabetes. Diabetes 50(5):1219-21.,Albertson RC,et al.(2005) Zebrafish acvr2a and acvr2b exhibit distinct roles in craniofacial development. Developmental dynamics 233(4): 1405-18. |
| URL | https://www.targetmol.com/recombinant-protein/acvr2b_protein_human_recombinant_ecd_hfc_tag_hplc_verified |
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