FLT1 Protein, Human, Recombinant (aa 1-328, His) [TMPY-00637]

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Synonyms	VEGFR-1, fms-related tyrosine kinase 1, VEGFR1, FLT, FLT-1
Characteristics	Measured by its ability to inhibit the VEGF-dependent proliferation of human umbilical vein endothelial cells ( HUVEC ). ( Conn, G.?et?al.?,1990 , Proc. Natl. Acad. Sci. USA 87:1323. )The ED50 for this effect is typically 10-40 ng/mL in the presence of 10 ng/mL human VEGF165.
Endotoxin Level	< 1.0 EU/μg of the protein as determined by the LAL method.
Purity	97.50%
Description	FLT1 Protein, Human, Recombinant (aa 1-328, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35.6 kDa and the accession number is L7RSL3.
Reference	Herley M.T.,et al.,(1999), Characterization of the VEGF binding site on the Flt-1 receptor.Biochem. Biophys. Res. Commun. 262:731-738.,Kendall R.L.,et al., (1993), Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor.Proc. Natl. Acad. Sci. U.S.A. 90:10705-10709.,Shibuya M.,et al.,(1990), Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family. Oncogene 5:519-524.
URL	https://www.targetmol.com/recombinant-protein/flt1_protein_human_recombinant_his_tag_

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