PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His) [TMPY-00408]

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Synonyms	FH3, proprotein convertase subtilisin/kexin type 9, LDLCQ1, HCHOLA3, NARC1, PC9, NARC-1
Characteristics	1.Measured by its binding ability in a functional ELISA. Immobilized human PCSK9-His(D374Y)at 10 μg/mL (100 μL /well) can bind biotinylated LDLR-His , The EC50 of biotinylated LDLR-His is 0.2-1.4μg/mL. 2.Loaded Recombinant Human LDLR/LDL Receptor Protein, mFc Tag on ProA Biosensor, can bind Human PCSK9 / NARC1 (D374Y, V474I, G670E) Protein, His Tag with an affinity constant of 3.08nM as determined in BLI assay (Routinely tested).
Endotoxin Level	< 1.0 EU/μg of the protein as determined by the LAL method.
Purity	98.60%
Description	PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.6 kDa and the accession number is AAV67948.1.
Reference	Shan, L. et al., 2008, Biochem. Biophys. Res. Commun. 375: 69-73.,Sseidah, N.G. et al., 2003, Proc. Natl. Acad. Sci. USA. 100: 928-933.,Beyer, T.P. et al., 2007, J. Lipid. Res. 48: 1488-1498,Abifadel, M. et al., 2003, Nat. Genet. 34: 154-156.,Benjannet, S. et al., 2005, J. Biol. Chem. 279: 48865-48875.
URL	https://www.targetmol.com/recombinant-protein/human_pcsk9_narc1_d374y_v474i_g670e_protein_his_tag_

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