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- サプライヤー
- TargteMol
- カタログNo.
- TMPY-00203
- 製品名称
- LOXL2 Protein, Mouse, Recombinant (His)
- タンパク質名
- LOXL2
- Species
- Mouse
- HOST
- HEK293 Cells
- 100μg: -
- お問い合わせ
Overview
| Synonyms | 1110004B06Rik, 4930526G11Rik, 9430067E15Rik, lysyl oxidase-like 2 |
|---|---|
| Characteristics | Measured by its ability to produce hydrogen peroxide during the oxidation of benzylamine. The specific activity is > 3pmoles/min/μg. |
| Endotoxin Level | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Purity | 86.10% |
| Description | Lysyl oxidase homolog 2, also known as Lysyl oxidase-like protein 2, Lysyl oxidase-related protein 2, Lysyl oxidase-related protein WS9-14 and LOXL2, is a secreted protein that belongs to the lysyl oxidase family. LOXL2 contains four SRCR domains. The lysyl oxidase family is made up of five members: lysyl oxidase (LOX) and lysyl oxidase-like 1-4 ( LOXL1, LOXL2, LOXL3, LOXL4 ). All members share conserved C-terminal catalytic domains that provide for lysyl oxidase or lysyl oxidase-like enzyme activity; and more divergent propeptide regions. LOX family enzyme activities catalyze the final enzymatic conversion required for the formation of normal biosynthetic collagen and elastin cross-links. LOXL2 is expressed by pre-hypertrophic and hypertrophic chondrocytes in vivo, and that LOXL2 expression is regulated in vitro as a function of chondrocyte differentiation. LOXL2 promotes chondrocyte differentiation by mechanisms that are likely to include roles as both a regulator and an effector of chondrocyte differentiation. LOXL2 expression could also be explored as a molecular target in the prevention of breast cancer progression. |
| Reference | R?ckert,F.?et al., 2010, Int J Colorectal Dis. 25?(3):303-11.Iftikhar,M. et al.,?2011, J Biol Chem. 286?(2):909-18.,Hollosi,P. et al., 2009, Int J Cancer. 125?(2):318-27.,Peng,L. et al., 2009, Carcinogenesis. 30 (10):1660-9. |
| URL | https://www.targetmol.com/recombinant-protein/loxl2_protein_mouse_recombinant_his_tag_ |
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