CDH3 Protein, Cynomolgus, Recombinant (His) [TMPK-01306]

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Synonyms	PCAD, CDH3, P-cadherin, PCADP-cadherin, CDHP, CAD3, Placental cadherin, HJMD, Cadherin-3
Characteristics	Anti-CDH3 Antibody captured on CM5 Chip via Protein A can bind Cynomolgus CDH3, His Tag with an affinity constant of 0.37 μM as determined in SPR assay.
Endotoxin Level	< 1 EU/μg by the LAL method.
Purity	> 95% as determined by Bis-Tris PAGE
Description	Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been proved it could be a serum marker to monitor colorectal cancer. Inhibited CDH3 expression could upregulate E-cadherin, downregulated N-cadherin, which may control invasion and migration. CDH3 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 61.11 kDa and the accession number is XP_005592414.1.
Reference	Zhou Y, et al. Downregulated CDH3 decreases proliferation, migration, and invasion in thyroid cancer. Am J Transl Res. 2020 Jun 15;12(6):3057-3067. PMID: 32655830; PMCID: PMC7344063.
URL	https://www.targetmol.com/recombinant-protein/cdh3_cadherin_3_protein_cynomolgus_recombinant_his_

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