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- サプライヤー
- TargteMol
- カタログNo.
- TMPK-01246
- 製品名称
- GDF-15 Protein, Mouse, Recombinant (His)
- タンパク質名
- GDF-15
- Species
- Mouse
- HOST
- E. coli
- 100μg: -
- お問い合わせ
Overview
| Synonyms | MIC1, Placental TGF-beta, Placental TGF-β, PTGF-beta, PTGFBPTGF-β, MIC-1, PTGFB, PTGFBPTGF-beta, PDF, NAG-1, PTGF-β, PLAB, GDF15, RG-1, GDF-15 |
|---|---|
| Characteristics | 1. Immobilized Mouse GDF15, His Tag at 5μg/ml (100μl/Well) on the plate. Dose response curve for Biotinylated Mouse GFRAL, His Tag with the EC50 of 0.25μg/ml determined by ELISA (QC Test). 2. Mouse GFRAL, His Tag immobilized on CM5 Chip can bind Mouse GDF15, His Tag with an affinity constant of 0.34 nM as determined in SPR assay. |
| Endotoxin Level | < 1 EU/μg by the LAL method. |
| Purity | SDS-PAGE: > 95% |
| Description | Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-His tag. The predicted molecular weight is 13.78 kDa and the accession number is Q9Z0J7. |
| Reference | Luan HH, et al. GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance. Cell. 2019 Aug 22;178(5):1231-1244.e1doi: 10.1016/j.cell.2019.07.033. Epub 2019 Aug 8. PMID: 31402172; PMCID: PMC6863354. |
| URL | https://www.targetmol.com/recombinant-protein/gdf15_protein_mouse_recombinant_his_ |
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