GDF-15 Protein, Mouse, Recombinant (hFc) [TMPK-01244]

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Synonyms	PTGFBPTGF-beta, PTGFB, PLAB, NAG-1, Placental TGF-β, RG-1, GDF15, GDF-15, PTGFBPTGF-β, MIC-1, PTGF-β, MIC1, Placental TGF-beta, PDF, PTGF-beta
Characteristics	Immobilized Mouse GFRAL, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Mouse GDF15, hFc Tag with the EC50 of 3.0ng/ml determined by ELISA.
Endotoxin Level	< 1 EU/μg by the LAL method.
Purity	> 95%
Description	Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 37.9 kDa and the accession number is Q9Z0J7.
Reference	Luan HH, et al. GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance. Cell. 2019 Aug 22;178(5):1231-1244.e1doi: 10.1016/j.cell.2019.07.033. Epub 2019 Aug 8. PMID: 31402172; PMCID: PMC6863354.
URL	https://www.targetmol.com/recombinant-protein/gdf15_protein_mouse_recombinant_hfc_

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