GDF-15 Protein, Rat, Recombinant (His) [TMPK-01243]

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Synonyms	GDF-15, MIC-1, PTGFB, MIC1, GDF15, PDF, PTGF-beta, PTGFBPTGF-beta, NAG-1, Placental TGF-β, PTGF-β, PLAB, PTGFBPTGF-β, Placental TGF-beta, RG-1
Characteristics	1. Immobilized Rat GDF-15, His Tag at 5 μg/mL (100 μL/well) on the plate. Dose response curve for Human GFRAL, hFc Tag with the EC50 of 8.0 ng/mL determined by ELISA. 2. Immobilized Rat GDF15, His Tag at 5 μg/mL (100 μL/well) on the plate. Dose response curve for Biotinylated Mouse GFRAL, His Tag with the EC50 of 0.95 μg/mL determined by ELISA.
Endotoxin Level	< 1 EU/μg by the LAL method.
Purity	SDS-PAGE: > 95%
Description	Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, including cancer and obesity. GDF15 is synthesized as pro-GDF15, is dimerized, and is cleaved and secreted into the circulation as a mature dimer GDF15. GDF-15 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-His tag. The predicted molecular weight is 13.68 kDa and the accession number is Q9Z0J6.
Reference	Baek SJ, Eling T. Growth differentiation factor 15 (GDF15): A survival protein with therapeutic potential in metabolic diseases. Pharmacol Ther. 2019 Jun;198:46-58. doi: 10.1016/j.pharmthera.2019.02.008. Epub 2019 Feb 18. PMID: 30790643; PMCID: PMC7196666.
URL	https://www.targetmol.com/recombinant-protein/gdf15_protein_rat_recombinant_his_

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