MD2/LY96 Protein, Human, Recombinant (His) [TMPK-01242]

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Synonyms	MD-2, Ly-96, ESOP-1, Lymphocyte antigen 96, LY96, ESOP1
Characteristics	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Endotoxin Level	< 1 EU/μg by the LAL method.
Purity	> 95%
Description	MD2, a 160-residue accessory glycoprotein, is responsible for the recognition and binding of Gram-negative bacterial membrane component, lipopolysaccharide (LPS).Internalization of pathogen inside the mononuclear phagocytes has also been attributed to MD2 which leads to the clearance of pathogens from the host. MD2/LY96 Protein, Human, Recombinant (His) is expressed in E. coli expression system with C-His tag. The predicted molecular weight is 18.07 kDa and the accession number is Q9Y6Y9-1.
Reference	Tandon A, et al. An MD2-derived peptide promotes LPS aggregation, facilitates its internalization in THP-1 cells, and inhibits LPS-induced pro-inflammatory responses. Cell Mol Life Sci. 2018 Jul;75(13):2431-2446. doi: 10.1007/s00018-017-2735-2. Epub 2018 Jan 8. PMID: 29313060.
URL	https://www.targetmol.com/recombinant-protein/md2_protein_human_recombinant_his_

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