Kallikrein 5/KLK5 Protein, Mouse, Recombinant (His) [TMPK-01158]

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Synonyms	SCTE, KLKL2, KLK5, KLK-L2, Klnc, Kallikrein c
Characteristics	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Endotoxin Level	< 1 EU/μg by the LAL method.
Purity	> 95%
Description	The inhibition of kallikrein 5 (KLK5) has been identified as a potential strategy for treatment of the genetic skin disorder Netherton syndrome, in which loss-of-function mutations in the SPINK5 gene lead to down-regulation of the endogenous inhibitor LEKTI-1 and profound skin-barrier defects with severe allergic manifestations. To aid in the development of a medicine for this target, an X-ray crystallographic system was developed to facilitate fragment-guided chemistry and knowledge-based drug-discovery approaches.
Reference	Thorpe JH, et al. Evaluation of a crystallographic surrogate for kallikrein 5 in the discovery of novel inhibitors for Netherton syndrome. Acta Crystallogr F Struct Biol Commun. 2019 May 1;75(Pt 5):385-39doi: 10.1107/S2053230X19003169. Epub 2019 Apr 26. PMID: 31045568; PMCID: PMC6497096.
URL	https://www.targetmol.com/recombinant-protein/kallikrein_5_klk5_protein_mouse_recombinant_his_

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