SEZ6 Protein, Human, Recombinant (His) [TMPK-00998]

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Synonyms	SEZ6, BSRPC, BSRP-C, SEZ-6
Characteristics	Immobilized Human SEZ6, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Anti-SEZ6 Antibody, hFc Tag with the EC50 of 13.2ng/ml determined by ELISA.
Endotoxin Level	< 1 EU/μg by the LAL method.
Purity	SDS-PAGE: > 95%
Description	Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 98.9 kDa and the accession number is Q53EL9-1.
Reference	Roitman M, et al. Sez6 levels are elevated in cerebrospinal fluid of patients with inflammatory pain-associated conditions. Pain Rep. 2019 Mar 25;4(2):e719. doi: 10.1097/PR9.0000000000000719. PMID: 31041421; PMCID: PMC6455686.
URL	https://www.targetmol.com/recombinant-protein/sez6_protein_human_recombinant_his_

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