CCR8 Protein, Human, Recombinant (hFc) [TMPK-00896]

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Synonyms	CD198, CY6, TER-1, CCR8, CMKBR8, TER1, GPRCY6, CKRL1, CCR-8, CDw198, ChemR1, CMKBRL2, GPR-CY6, CKR-L1
Characteristics	Immobilized Human?CCR8, hFc Tag at 1μg/ml (100μl/well) on the plate. Dose response curve for Biotinylated Anti-CCR8 Antibody, hFc Tag with the EC50 of 17.6ng/ml determined by ELISA.
Endotoxin Level	< 1 EU/μg by the LAL method.
Purity	> 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
Description	CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. CCR8 may regulate monocyte chemotaxis and thymic cell line apoptosis and is alternative coreceptor with CD4 for HIV-1 infection. CCR8 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 30.62 kDa and the accession number is P51685-1.
Reference	Berenguer J, et al. Glycosylated extracellular vesicles released by glioblastoma cells are decorated by CCL18 allowing for cellular uptake via chemokine receptor CCR8. J Extracell Vesicles. 2018 Mar 13;7(1):1446660.
URL	https://www.targetmol.com/recombinant-protein/ccr8_protein_human_recombinant_hfc_

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