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- サプライヤー
- TargteMol
- カタログNo.
- TMPK-00807
- 製品名称
- Osteopontin Protein, Mouse, Recombinant (His)
- タンパク質名
- Osteopontin
- Species
- Mouse
- HOST
- HEK293 Cells
- 100μg: -
- お問い合わせ
Overview
| Synonyms | ETA-1, Bone sialoprotein 1, BNSP, SPP-1, Osteopontin, Nephropontin, Uropontin, BSPI, BSP-1, SPP1, OPN |
|---|---|
| Characteristics | Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Endotoxin Level | < 1 EU/μg by the LAL method. |
| Purity | > 95% |
| Description | Secreted phosphoprotein 1 (SPP1) expression in TAMs isolated from lung adenocarcinoma tissues and PMA-treated THP-1 cells were measured. Macrophage polarization was identified by flow cytometric analysis. Cell migration and apoptosis were assessed by Transwell migration assays and flow cytometric analysis, respectively. SPP1 is highly expressed in tumor tissues and TAMs isolated from patients with an advanced TNM stage, and also in PMA-treated THP-1 cells. |
| Reference | Zhang Y, et al. Upregulation of PD-L1 by SPP1 mediates macrophage polarization and facilitates immune escape in lung adenocarcinoma. Exp Cell Res. 2017 Oct 15;359(2):449-457. doi: 10.1016/j.yexcr.2017.08.028. Epub 2017 Aug 19. PMID: 28830685. |
| URL | https://www.targetmol.com/recombinant-protein/spp1_opn_protein_mouse_recombinant_his_ |
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