LRP-5 Protein, Human, Recombinant (mFc) [TMPK-00740]

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Synonyms	EVR4, VBCH2, OPS, BMND1OPTA1, LR3, OPPG, LRP-7, OPTA1, LRP-5, BMND1, LRP7, EVR1, LR3VBCH2, HBM, LRP5
Characteristics	Immobilized Human DKK1, His Tag at 5μg/ml (100μl/well) on the plate. Dose response curve for Human LRP-5, mFc Tag with the EC50 of 0.11μg/ml determined by ELISA.
Endotoxin Level	< 1 EU/μg by the LAL method.
Purity	> 95% as determined by Bis-Tris PAGE
Description	A role for low-density lipoprotein-related receptor 5 (LRP5) in human bone was first established by the identification of genetic alterations that led to dramatic changes in bone mass. Shortly thereafter, mutations that altered the function of the sclerostin (SOST) gene were also associated with altered human bone mass. Subsequent studies of LRP5 and sclerostin have provided important insights into the mechanisms by which these proteins regulate skeletal homeostasis. LRP-5 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 96 kDa and the accession number is O75197-1.
Reference	Williams BO. LRP5: From bedside to bench to bone. Bone. 2017 Sep;102:26-30. doi: 10.1016/j.bone.2017.03.044. Epub 2017 Mar 2 PMID: 28341377.
URL	https://www.targetmol.com/recombinant-protein/lrp_5_protein_human_recombinant_mfc_

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