LILRB4/CD85k/ILT3 Protein, Human, Recombinant (hFc) [TMPK-00603]

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Synonyms	HM18, ILT3, LIR5, LILRB4, ILT-3, CD85K
Characteristics	1. Immobilized Human LILRB4, hFc Tag at 0.2μg/ml (100μl/well) on the plate. Dose response curve for Biotinylated Anti-LILRB4 Antibody, hFc Tag with the EC50 of 16.1ng/ml determined by ELISA (QC Test). 2. Human LILRB4, hFc Tag captured on CM5 Chip via Protein A can bind Human APOE 4, His Tag with an affinity constant of 74.20 nM as determined in SPR assay.
Endotoxin Level	< 1 EU/μg by the LAL method.
Purity	SDS-PAGE: > 95%; SEC-HPLC: > 95%
Description	LILRB4,also known as CD85k and LIR-5, ILT3,? is an approximately 60 kDa transmembrane glycoprotein that negatively regulates immune cell activation. Mature human ILT3 consists of a 238 amino acid (aa) extracellular domain with two Ig-like domains, a 21 aa transmembrane segment, and a 168 aa cytoplasmic domain with 3 immunoreceptor tyrosine-based inhibitory motifs (ITIM).LILRB4 is receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. LILRB4/CD85k/ILT3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 52.6 kDa and the accession number is AAH26309.
Reference	Samuel J, et al. A Novel Anti-LILRB4 CAR-T Cell for the Treatment of Monocytic AML[J]. Molecular Therapy, 2018:S1525001618303721-.
URL	https://www.targetmol.com/recombinant-protein/lilrb4_cd85k_ilt3_protein_human_recombinant_hfc_

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