PSMA Protein, Human, Recombinant (hFc) [TMPK-00370]

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Synonyms	NAALAdase, FOLH1, FOLHNAALADase I, FGCP, mGCP, PSMAFGCP, NAALADase I, GCPIImGCP, Folate hydrolase 1, FOLH, NAALAD1, GCPII, PSM, GIG27, PSMA, GCP2
Characteristics	Immobilized Human PSMA, hFc Tag at 2μg/ml (100μl/Well) on the plate. Dose response curve for Biotinylated Anti-PSMA Antibody, hFc Tag with the EC50 of 16.3ng/ml determined by ELISA.
Endotoxin Level	< 1 EU/μg by the LAL method.
Purity	> 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
Description	Prostate-specific membrane antigen (PSMA) is an enzyme that in humans is encoded by the FOLH1 (folate hydrolase 1) gene, also known as Glutamate carboxypeptidase II (GCPII). Human PSMA is highly expressed in the prostate, roughly a hundred times greater than in most other tissues. In some prostate cancers, PSMA is the second-most upregulated gene product, with an 8- to 12-fold increase over levels in noncancerous prostate cells. PSMA Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 106.8 kDa and the accession number is Q04609-1.
Reference	Song C, et al. Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody-drug Conjugate Targeting PSMA, in Pre-clinical Models of Prostate Cancer[J]. Molecular Cancer Therapeutics, 2018:molcanther.0982.2017-.
URL	https://www.targetmol.com/recombinant-protein/psma_folh1_protein_human_recombinant_hfc_

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