IFN-alpha 1/IFNA1 Protein, Mouse, Recombinant (hFc) [TMPK-00074]

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Synonyms	Interferon α-D, IFNα1, IFN-alpha-1, IFN α1, LeIF D, IFN α 1, IFN-α-1, Interferon α1, IFNA1, Interferon alpha 1, Interferon alpha-D, IFN-alpha-1/13, IFN-α-1/13, IFN alpha1, Interferon α-1/13, Interferon alpha-1/13, IFNalpha 1
Characteristics	Human IFN alpha/beta R1, His Tag captured on CM5 Chip via anti-his antibody can bind Mouse IFN alpha 1, hFc Tag with an affinity constant of 11.96 nM as determined in SPR assay.
Endotoxin Level	< 1 EU/μg by the LAL method.
Purity	> 95% as determined by Bis-Tris PAGE
Description	IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by upregulating inflammation, endoplasmic reticulum (ER) stress and MHC class I overexpression, three hallmarks of islet histology in early type 1 diabetes. IFN-alpha 1/IFNA1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 45.88 kDa and the accession number is P01572.
Reference	Coomans de Brach?ne A, et al. IFN-α induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells. Diabetologia. 2018 Mar;61(3):636-640. doi: 10.1007/s00125-017-4536-4. Epub 2018 Jan 5. PMID: 29305625; PMCID: PMC6241216.
URL	https://www.targetmol.com/recombinant-protein/ifn_alpha_1_protein_mouse_recombinant_hfc_

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