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- サプライヤー
- TargteMol
- カタログNo.
- TMPJ-01466
- 製品名称
- Osteoprotegerin Protein, Human, Recombinant (aa 22-401, His)
- タンパク質名
- Osteoprotegerin
- Species
- Human
- HOST
- HEK293 Cells
- 10μg: -
- お問い合わせ
Overview
| Synonyms | OPG, Tumor Necrosis Factor Receptor Superfamily Member 11B, OCIF, TNFRSF11B, Osteoclastogenesis Inhibitory Factor, Osteoprotegerin |
|---|---|
| Characteristics | Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Endotoxin Level | < 0.1 ng/?g (1 EU/?g) as determined by LAL test. |
| Purity | 99% |
| Description | TNFRSF11B is a secreted protein, containing 2 death domains and 4 TNFR-Cys repeats. TNFRSF11B is a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL). By binding RANKL, TNFRSF11B inhibits nuclear kappa B (NF-κB) which is a central and rapid acting transcription factor for immune-related genes, and a key regulator of inflammation, innate immunity, and cell survival and differentiation. TNFRSF11B levels are influenced by voltage-dependent calcium channelsCav1.2. TNFRSF11B can reduce the production of osteoclasts by inhibiting the differentiation of osteoclast precursors (osteoclasts are related to monocytes/macrophages and are derived from granulocyte/macrophage-forming colony units (CFU-GM)) into osteoclasts and also regulates the resorption of osteoclasts in vitroand in vivo. TNFRSF11B binding to RANKL on osteoblast/stromal cells, blocks the RANKL-RANK ligand interaction between osteoblast/stromal cells and osteoclast precursors. This has the effect of inhibiting the differentiation of the osteoclast precursor into a mature osteoclast. |
| Reference | - |
| URL | https://www.targetmol.com/recombinant-protein/osteoprotegerin_protein_human_recombinant_glu22_leu401_his_ |
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