GM-CSF/CSF2 Protein, Human, Recombinant (E. coli) [TMPJ-01465]

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Synonyms	Colony-Stimulating Factor, CSF2, CSF, Sargramostim, Molgramostin, Granulocyte-Macrophage Colony-Stimulating Factor, GMCSF, GM-CSF
Characteristics	Measured in a cell proliferation assay using TF?1 human erythroleukemic cells.The ED50 for this effect is 4-20 pg/ml. (QC verified)
Endotoxin Level	< 0.001 ng/?g (0.01 EU/?g) as determined by LAL test.
Purity	> 99.9%
Description	Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is produced by a number of different cell types (including activated T cells, B cells, macrophages, mast cells, endothelial cells and fibroblasts) in response to cytokine of immune and inflammatory stimuli. Besides granulocyte-macrophage progenitors, GM-CSF is also a growth factor for erythroid, megakaryocyte and eosinophil progenitors. On mature hematopoietic, monocytes/ macrophages and eosinophils. GM-CSF has a functional role on non-hematopoitic cells. It can induce human endothelial cells to migrate and proliferate. Additionally, GM-CSF can also stimulate the proliferation of a number of tumor cell lines, including osteogenic sarcoma, carcinoma and adenocarcinoma cell lines.
Reference	-
URL	https://www.targetmol.com/recombinant-protein/gm_csf_csf2_protein_human_recombinant_e_coli_

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