検索タンパク質、抗体、アッセイキット
タンパク質カタログ
輸入に関する法規制チェックは、御見積のご依頼をいただいた際に行います。
法規制によっては、定価として記載の価格に追加の費用が発生する場合や供給出来ない場合がございますので、あらかじめご了承ください。
- サプライヤー
- TargteMol
- カタログNo.
- TMPJ-01461
- 製品名称
- IL-15RA & IL-15 Protein, Human, Recombinant (hFc)
- タンパク質名
- IL-15RA & IL-15
- Species
- Human
- HOST
- HEK293 Cells
- 10μg: -
- お問い合わせ
Overview
| Synonyms | IL-15 Receptor α & IL-15 Fusion Protein, Interleukin-15, IL15RA&IL15 Complex, IL-15 Receptor alpha & IL-15 Fusion Protein, IL-15, IL15, IL15RA&IL15 |
|---|---|
| Characteristics | Measured in a cell proliferation assay using CTLL?2 mouse cytotoxic T cells.The ED50 for this effect is 5-20 ng/mL. |
| Endotoxin Level | < 0.1 ng/?g (1 EU/?g) as determined by LAL test. |
| Purity | 98% |
| Description | IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells.IL-15 is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 binds to the alpha subunit of the IL-15RA with high affinity. IL-15 also binds to the beta and gamma chains of the IL-2 receptor, but not the alpha subunit of the IL2 receptor. IL-15 is structurally and functionally related to IL-2. Both cytokines share some subunits of receptors, allowing them to compete for and negatively regulate each other's activity. The number of CD8+ memory T cells is controlled by a balance between IL-15 and IL-2. Despite their many overlapping functional properties, IL-2 and IL-15 are, in fact, quite distinct players in the immune system. IL-15 is constitutively expressed by a wide variety of cell types and tissues, including monocytes, macrophages and DCs. |
| Reference | - |
| URL | https://www.targetmol.com/recombinant-protein/il_15ra_il_15_protein_human_recombinant_hfc_ |
お問い合わせリスト