IL-33 Protein, Mouse, Recombinant [TMPJ-01210]

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Synonyms	Interleukin-1 family member 11, NF-HEV and IL- 1F11, NKHEV, IL-33, Interleukin 33, DVS27, IL33, C9orf26
Characteristics	Immobilized Mouse IL-33 at 5μg/ml (100 μl/well) can bind Mouse ST2-Fc. The ED50 of Mouse ST2-Fc is 0.33 ug/ml. (Regularly tested)
Endotoxin Level	< 0.001 ng/?g (0.01 EU/?g) as determined by LAL test.
Purity	SDS-PAGE: 96.3%; SEC-HPLC: 95%
Description	Mouse Interleukin 33 (IL-33) is a 30 kDa proinflammatory cytokine which may also regulates gene transcription in producer cells. IL-33 is constitutively expressed in smooth muscle and airway epithelia. IL-33 was identified based on sequence and structural homology with IL-1 family cytokines. It is up?regulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1 alpha or IL?1 beta stimulation. IL-33 is structurally related to IL-1, which induces helper T cells to produce type 2 cytokines and acts through the receptor IL1RL-1. BindingIL-33 to this receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce cytokines. In vivo, IL-33 induces the expression of IL-4, IL-5, IL-13 and also leads to severe pathological changes in mucosal organs.
Reference	-
URL	https://www.targetmol.com/recombinant-protein/il_33_protein_mouse_recombinant

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