TPSAB1 Protein, Human, Recombinant (His) [TMPJ-01204]

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Synonyms	TPS1, tryptase alpha/beta 1, TPS2, tryptase α/β1, tryptase α/β 1, TPSB1, Tryptase 1, TPSAB1
Characteristics	Loaded Anti-Human Tryptase mAb-Fc on Protein A Biosensor, can bind Human TPSAB1-His with an affinity constant of 0.92 nM as determined in BLI assay. (Regularly tested)
Endotoxin Level	< 0.1 ng/?g (1 EU/?g) as determined by LAL test.
Purity	98%
Description	Tryptases are serine proteases with trypsin-like specificity. Together with chymases and Cathepsin G, tryptases are important players in mast cell mediation of inflammatory and allergic responses. Tryptase alpha/beta-1(TPSAB1), also known as mast cell protease 7 (MCPT7), it exhibits anticoagulant activity due to its ability to degrade fibrinogen in the presence of a diverse array of protease inhibitors in plasma. The two Isoform 1 and isoform 2 are expressed in lung, stomach, spleen, heart and skin; in these tissues, isoform 1 is predominant. Isoform 2 is expressed in aorta, spleen, and breast tumor, with highest levels in the endothelial cells of some blood vessels surrounding the aorta, as well as those surrounding the tumor and low levels, if any, in mast cells. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates. It may play a role in innate immunity.
Reference	-
URL	https://www.targetmol.com/recombinant-protein/tpsab1_protein_human_recombinant_his_

バイオ製品Bio Products