検索タンパク質、抗体、アッセイキット
タンパク質カタログ
輸入に関する法規制チェックは、御見積のご依頼をいただいた際に行います。
法規制によっては、定価として記載の価格に追加の費用が発生する場合や供給出来ない場合がございますので、あらかじめご了承ください。
- サプライヤー
- TargteMol
- カタログNo.
- TMPJ-01172
- 製品名称
- IL-17 Protein, Mouse, Recombinant (His)
- タンパク質名
- IL-17
- Species
- Mouse
- HOST
- HEK293 Cells
- 10μg: -
- お問い合わせ
Overview
| Synonyms | CTLA8, IL-17, IL-17A, Interleukin-17A, CTLA-8, Cytotoxic T-Lymphocyte-Associated Antigen 8, IL17, IL17A |
|---|---|
| Characteristics | 1. Loaded Biotinylated Human IL-17RA -His-Avi on SA Biosensor, can bind Mouse IL-17A-His with an affinity constant of 12.6 nM as determined in BLI assay. (Regularly tested) 2. Measured by its ability to induce IL-6 secretion by NIH?3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 0.25-1.25 ng/ml. (QC verified) |
| Endotoxin Level | < 0.001 ng/?g (0.01 EU/?g) as determined by LAL test. |
| Purity | > 99% |
| Description | Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Mature mouse IL-17A shares 61% and 89% amino acid sequence identity with human and rat IL-17A, respectively. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation. |
| Reference | - |
| URL | https://www.targetmol.com/recombinant-protein/il_17a_protein_mouse_recombinant_his_ |
お問い合わせリスト