VEGF165 Protein, Human, Recombinant [TMPJ-00864]

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Synonyms	Vascular Endothelial Growth Factor Isoform 165, VEGF165
Characteristics	1. Loaded Human VEGFR1-Fc on Protein A Biosensor, can bind Human VEGF165 with an affinity constant of 0.29 nM as determined in BLI assay.?(Regularly tested) 2. Immobilized Human VEGF165 at 2μg/ml (100 μl/well) can bind Human VEGF165 antibody. The ED50 of Human VEGF165 antibody is 1.44 ng/ml. (Regularly tested)
Endotoxin Level	< 0.001 ng/?g (0.01 EU/?g) as determined by LAL test.
Purity	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Description	Human Vascular endothelial growth factor (VEGF), also known as VEGF-A and vascular permeability factor (VPF), belongs to the platelet-derived growth factor family of cysteine-knot growth factors. It is a potent activator in vasculogenesis and angiogenesis both physiologically and pathologically. VEGF-A has 8 differently spliced isoforms, of which VEGF165 is the most abundant one. VEGF165 is a disulfide-linked homodimer consisting of two glycosylated 165 amino acid polypeptide chains. VEGF stimulates the cellular response through binding to tyrosine kinase receptors VEGFR1 and VEGFR2 on the cell surface. It is widely accepted that VEGFR2 mediate almost all of the known cellular responses to VEGF while the function of VEGFR1 is less defined and is thought to modulate the VEGFR2 signaling.
Reference	-
URL	https://www.targetmol.com/recombinant-protein/vegf165_protein_human_recombinant

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