TL1A/TNFSF15 Protein, Mouse, Recombinant [TMPJ-00603]

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Synonyms	TNFSF15, VEGI, Vascular Endothelial Cell Growth Inhibitor, Tumor Necrosis Factor Ligand Superfamily Member 15, TL1, TNF Ligand-Related Molecule 1
Characteristics	1. Loaded TL1A Antibody-Fc on Protein A Biosensor, can bind Mouse TL1A-None with an affinity constant of 12.8 pM as determined in BLI assay. (Regularly tested) 2. Immobilized Recombinant Mouse TL1A at 2μg/ml (100 μl/well) can bind Human TL1A Antibody (9H5). The ED50 of Human TL1A Antibody (9H5) is 1.73 ng/ml. (Regularly tested)?
Endotoxin Level	< 0.1 ng/?g (1 EU/?g) as determined by LAL test.
Purity	SDS-PAGE: 95%; SEC-HPLC: > 99.9%
Description	Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) is a new member of the tumor necrosis factor family. TNFSF15 is predominantly an endothelial cell-specific gene, and recombinant TNFSF15 is a potent inhibitor of endothelial cell proliferation, angiogenesis and tumor growth. TNFSF15 exerts two activities on endothelial cells: early G1 arrest of G0/G1-cells responding to growth stimuli and programmed cell death of proliferating cells. These activities are highly specific to endothelial cells. TNFSF15 is also able to regulate the expression of several important genes involved in angiogenesis. These findings are consistent with the view that TNFSF15 functions as an autocrine cytokine to inhibit angiogenesis and stabilize the vasculature.
Reference	-
URL	https://www.targetmol.com/recombinant-protein/tl1a_protein_mouse_recombinant

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