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- サプライヤー
- TargteMol
- カタログNo.
- TMPJ-00387
- 製品名称
- IL-4R alpha Protein, Mouse, Recombinant (hFc)
- タンパク質名
- IL-4R alpha
- Species
- Mouse
- HOST
- HEK293 Cells
- 10μg: -
- お問い合わせ
Overview
| Synonyms | IL4-BP, Soluble IL-4R-alpha, Interleukin-4 receptor subunit alpha, Soluble IL-4R-α, Interleukin-4 receptor subunit α, CD124, IL-4R-α, IL-4R-alpha |
|---|---|
| Characteristics | 1. Loaded Mouse IL-4-His on HIS1K Biosensor, can bind Mouse IL-4RA-Fc with an affinity constant of <10<sup>-3</sup> nM as determined in BLI assay.?(Regularly tested) 2. Immobilized Mouse IL-4RA-Fc at 2μg/ml (100 μl/well)can bind Mouse IL-4-His . The ED50 of Mouse IL-4-Hisis 4.32 ng/ml. (Regularly tested) |
| Endotoxin Level | < 0.1 ng/?g (1 EU/?g) as determined by LAL test. |
| Purity | 98.80% |
| Description | Interleukin-4 receptor subunit alpha(IL-4RA), alos known as Soluble IL-4 receptor subunit alpha, belongs to the type I cytokine receptor family and type 4 subfamily. It expressed in both Th1 and Th2 cells. It functions as receptor for both interleukin 4 and interleukin 13 and couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and chemokine and mucus production at sites of allergic inflammation. In certain cell types, IL-4RA can signal through activation of insulin receptor substrates, IRS1/IRS2. The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequently it recruits to the complex of the common gamma chain. In immune cells, IL-4RA creates a type I receptor. In non-immune cells, it forms a type II receptor with of IL13RA1. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor and interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP. |
| Reference | - |
| URL | https://www.targetmol.com/recombinant-protein/il_4ra_protein_mouse_recombinant_hfc_ |
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