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- サプライヤー
- TargteMol
- カタログNo.
- TMPJ-00375
- 製品名称
- HGF Protein, Human, Recombinant (His)
- タンパク質名
- HGF
- Species
- Human
- HOST
- HEK293 Cells
- 10μg: -
- お問い合わせ
Overview
| Synonyms | Scatter factor, Hepatocyte growth factor, HGF, SF, Hepatopoietin-A, HPTA |
|---|---|
| Characteristics | Measured by its ability to induce IL-11 secretion by Saos?2 human osteosarcoma cells.? The ED50 for this effect is 0.3-1.5 ng/ml. (QC verified) |
| Endotoxin Level | < 0.001 ng/?g (0.01 EU/?g) as determined by LAL test. |
| Purity | SDS-PAGE: > 99.9%; SEC-HPLC: 99.1% |
| Description | HGF, is a pleiotropic protein in the Plasminogen subfamily of S1 peptidases and contains 4 kringle domains, 1 PAN domain and 1 peptidase S1 domain. HGF is secreted as an inactive 728 amino acid (aa) single chain propeptide. It is cleaved after the fourth Kringle domain by a serine protease to form bioactive disulfide-linked HGF with a 60 kDa alpha and 30 kDa beta chain. HGF binds heparan-sulfate proteoglycans and the widely expressed receptor tyrosine kinase, HGF R/c-MET. HGF regulates epithelial morphogenesis by inducing cell scattering and branching tubulogenesis. It can also alter epithelium morphology by the induction of nectin-1 alpha ectodomain shedding, an adhesion protein component of adherens junctions. HGF regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto oncogenic c-Met receptor. HGF is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. |
| Reference | - |
| URL | https://www.targetmol.com/recombinant-protein/hgf_protein_human_recombinant_his_ |
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