TGF beta 1 Protein, Human, Recombinant (Avi), Biotinylated [TMPJ-00249]

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Synonyms	TGF-Beta-1, TGFB1, Transforming Growth Factor β-1, Latency-Associated Peptide, TGF-β-1, Transforming Growth Factor Beta-1, TGFB, LAP, TGF-β1
Characteristics	1. Measured by its ability to inhibit TGF-beta 1 activity on TF?1 human erythroleukemic cells. The ED50?for this effect is 137.37pg/ml. (Regularly tested) 2. Immobilized Biotinylated Human TGF-beta 1-Avi at 2μg/ml (100 μl/well) can bind Human TGFBR2-Fc. The ED50 of Human TGFBR2-Fc is 9.47ng/ml. (Regularly tested)
Endotoxin Level	< 10 EU/mg of the protein as determined by the LAL method.
Purity	98.60%
Description	Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFβ-1 peptide. TGFβ-1 may also form heterodimers with other TGFβ family members. It has been found that TGFβ-1 is frequently upregulated in tumor cells. Mutations in this gene results in Camurati-Engelmann disease.
Reference	-
URL	https://www.targetmol.com/recombinant-protein/tgf_beta_1_protein_human_recombinant_avi_biotinylated

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