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タンパク質カタログ
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- サプライヤー
- TargteMol
- カタログNo.
- TMPJ-00166
- 製品名称
- SCF Protein, Mouse, Recombinant
- タンパク質名
- SCF
- Species
- Mouse
- HOST
- E. coli
- 10μg: -
- お問い合わせ
Overview
| Synonyms | MGF, Steel factor, Mast cell growth factor, SCF, Hematopoietic growth factor KL, Stem cell factor, Kit ligand |
|---|---|
| Characteristics | Measured by the dose-dependent stimulation of TF-1 cells. The ED50 for this effect is 4-12 ng/ml. (QC verified) |
| Endotoxin Level | < 0.001 ng/?g (0.01 EU/?g) as determined by LAL test. |
| Purity | > 99.9% |
| Description | Mouse stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. |
| Reference | - |
| URL | https://www.targetmol.com/recombinant-protein/scf_protein_mouse_recombinant |
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