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- サプライヤー
- TargteMol
- カタログNo.
- TMPJ-00137
- 製品名称
- APRIL/TNFSF13 Protein, Human, Recombinant (Flag & His)
- タンパク質名
- APRIL/TNFSF13
- Species
- Human
- HOST
- HEK293 Cells
- 10μg: -
- お問い合わせ
Overview
| Synonyms | TNF- and APOL-related leukocyte expressed ligand 2, TRDL-1, CD256, TALL-2, APRIL, Tumor necrosis factor ligand superfamily member 13, TNF-related death ligand 1, A proliferation-inducing ligand, TNFSF13 |
|---|---|
| Characteristics | 1. Loaded Cynomolgus BCMA-Fc on Protein A Biosensor, can bind Human APRIL-His with an affinity constant of 0.005 nM as determined in BLI assay. (Regularly tested) 2. Immobilized Human APRIL -Flag-His at 1μg/ml (100 μl/well) can bind Cynomolgus BCMA-Fc. The ED50 of Cynomolgus BCMA-Fc is 4.23 ng/ml. (Regularly tested); |
| Endotoxin Level | < 0.1 ng/?g (1 EU/?g) as determined by LAL test. |
| Purity | 99% |
| Description | APRIL (a proliferation-inducing ligand), also known as TNFSF13, TALL2, TRDL1, and CD256, is a member of the TNF ligand superfamily. It is synthesized as a 32 kDa proprotein which is cleaved by furin in the Golgi to release the active 17 kDa soluble molecule. Secreted human APRIL, which consists almost entirely of a single TNF homology domain, shares 85% amino acid sequence identity with mouse and rat APRIL. Both APRIL and its close relative BAFF bind and signal through the TNF superfamily receptors TACI and BCMA, while BAFF additionally functions through BAFF R. APRIL binds to heparan sulfate proteoglycans (HSPGs) independently of its binding to TACI and BCMA. APRIL can form bioactive heterotrimers with BAFF, and these circulate in the serum of patients with rheumatic immune disorders. APRIL enhances the proliferation and survival of plasma cells and also promotes T cell-dependent humoral responses. APRIL levels are elevated in the serum during coronary artery disease, and it is also elevated in many cancers primarily due to expression by tumor-infiltratin neutrophils. |
| Reference | - |
| URL | https://www.targetmol.com/recombinant-protein/april_protein_human_recombinant_flag_his_ |
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