検索タンパク質、抗体、アッセイキット
タンパク質カタログ
輸入に関する法規制チェックは、御見積のご依頼をいただいた際に行います。
法規制によっては、定価として記載の価格に追加の費用が発生する場合や供給出来ない場合がございますので、あらかじめご了承ください。
- サプライヤー
- TargteMol
- カタログNo.
- TMPJ-00071
- 製品名称
- EPO/Erythropoietin Protein, Human, Recombinant (His)
- タンパク質名
- EPO/Erythropoietin
- Species
- Human
- HOST
- HEK293 Cells
- 10μg: -
- お問い合わせ
Overview
| Synonyms | Erythropoietin, EPO, Epoetin |
|---|---|
| Characteristics | Measured in a cell proliferation assay using TF?1 human erythroleukemic cells. The ED50 for this effect is 80-250 pg/ml. (QC verified) |
| Endotoxin Level | < 0.1 ng/?g (1 EU/?g) as determined by LAL test. |
| Purity | 99% |
| Description | Erythropoietin (EPO) is a glycoprotein hormone that is principally known for its role in erythropoiesis, where it is responsible for stimulating proliferation and differentiation of erythroid progenitor cells. Erythropoietin is a member of the EPO/TPO family. It is a secreted, glycosylated cytokine composed of four alpha helical bundles. The differentiation of CFU-E (Colony Forming Unit-Erythroid) cells into erythrocytes can only be accomplished in the presence of EPO. Physiological levels of EPO in adult mammals are maintained primarily by the kidneys, whereas levels in fetal or neonatal mammals are maintained by the liver. EPO also can exert various non-hematopoietic activities, including vascularization and proliferation of smooth muscle, neural protection during hypoxia, and stimulation of certain B cells. Genetic variation in erythropoietin is associated with susceptbility to microvascular complications of diabetes type 2. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. |
| Reference | - |
| URL | https://www.targetmol.com/recombinant-protein/epo_protein_human_recombinant_his_ |
お問い合わせリスト