IL-7 Protein, Mouse, Recombinant (His) [TMPJ-00038]

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Synonyms	interleukin-7, IL-7, IL-7 interleukin-7, PBGF, Lymphopoietin -1
Characteristics	1. Loaded Mouse IL-7RA-Fc on Protein A Biosensor, can bind Mouse IL-7-His with an affinity constant of 18.9 nM as determined in BLI assay. (Regularly tested) 2. Measured in a cell proliferation assay using PHA-activated human peripheral blood lymphocytes (PBL). The ED50 for this effect is 60-1000 pg/ml. (QC verified)
Endotoxin Level	< 0.1 ng/?g (1 EU/?g) as determined by LAL test.
Purity	> 99.9%
Description	Mouse interleukin-7(IL-7) is the member of hemopoietin family which is important to the differentiation, proliferation, and survival of lymphocyte. Mouse IL-7 shares approximately 88% aa sequence identity with rat IL-7 and 58-60% with human, equine, bovine, ovine, porcine, feline and canine IL-7. It is widely expressed in primary and secondary lymphoid tissues cell and stromal epithelial cells of the thymus, bone marrow, and intestines. IL-7 activation of IL-7 R alpha is critical for both T cell and B cell lineage development. It is important for proliferation during certain stages of B-cell maturation. IL-7 contributes to the maintenance of all na?ve and memory T cells, mainly by promoting expression of the anti-apoptotic protein Bcl-2. It is required for optimal T cell-dendritic cell interaction.
Reference	-
URL	https://www.targetmol.com/recombinant-protein/il_7_protein_mouse_recombinant_his_

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