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タンパク質カタログ
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- サプライヤー
- TargteMol
- カタログNo.
- TMPH-02549
- 製品名称
- FHIT Protein, Mouse, Recombinant (His)
- タンパク質名
- FHIT
- Species
- Mouse
- HOST
- E. coli
- 20μg: -
- お問い合わせ
Overview
| Synonyms | Adenylylsulfatase, Adenylylsulfate-ammonia adenylyltransferase, Bis(5'-adenosyl)-triphosphatase, Adenosine 5'-monophosphoramidase FHIT, Fhit, Diadenosine 5',5'''-P1,P3-triphosphate hydrolase, AP3A hydrolase, Dinucleosidetriphosphatase, Fragile histidine triad protein |
|---|---|
| Characteristics | Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Endotoxin Level | - |
| Purity | 98% |
| Description | Possesses dinucleoside triphosphate hydrolase activity. Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Exhibits adenylylsulfatase activity, hydrolyzing adenosine 5'-phosphosulfate to yield AMP and sulfate. Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2. Exhibits adenylylsulfate-ammonia adenylyltransferase, catalyzing the ammonolysis of adenosine 5'-phosphosulfate resulting in the formation of adenosine 5'-phosphoramidate. Also catalyzes the ammonolysis of adenosine 5-phosphorofluoridate and diadenosine triphosphate. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity. Functions as tumor suppressor. |
| Reference | - |
| URL | https://www.targetmol.com/recombinant-protein/fhit_protein_mouse_recombinant_his |
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