Biotinylated Cynomolgus/Rhesus macaque TL1A / TNFSF15 Protein, Avitag?,His Tag (MALS verified) [TLA-C82E3]

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サプライヤー: AcroBioSystems
カタログNo.: TLA-C82E3
製品名称: Biotinylated Cynomolgus/Rhesus macaque TL1A / TNFSF15 Protein, Avitag?,His Tag (MALS verified)
タンパク質名: TL1A
Species: Cynomolgus / Rhesus macaque
HOST: HEK293

Synonyms	-
Characteristics	This protein carries an Avi tag (Avitag?) at the N-terminus, followed by a polyhistidine tag. The protein has a calculated MW of 23.7 kDa. The protein migrates as 26 kDa, 30 kDa and 33 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	1.0 EU per μg
Purity	90%
Description	TL1A, also known as TNFSF15, is a member of the TNF superfamily. This type II transmembrane protein forms stable homotrimers via its TNF homology domain (THD) and is expressed in immune cells, including monocytes, macrophages, dendritic cells, and T cells, as well as non-immune cells like synovial fibroblasts and endothelial cells. By binding to Death Receptor 3 (DR3), TL1A modulates proliferation, activation, apoptosis, and cytokine/chemokine production in effector cells, contributing to both innate and adaptive immune homeostasis. Dysregulated TL1A expression is implicated in autoimmune diseases such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease, making it a promising therapeutic target for conditions like ulcerative colitis and Crohn's disease.
Reference	4578
URL	https://www.acrobiosystems.com/products/protein/tl1a-cynomolgus-rhesus-macaque-tla-c82e3

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